乳腺浸润性小叶癌影像诊断

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Lobular neoplasia is characterized by small monomorphic cells that fill and distend the TDLU (terminal duct lobular unit )and spread through the ductal system

In ILC, malignant cells typically infiltrate and invade the breast stroma in single files

ILC often do not destroy anatomical structures or incite a connective tissue response, and mass lesions are less frequently

乳腺浸润性小叶癌是乳腺癌的一个特殊类型,占浸润性乳腺癌的5-15%

乳腺浸润性小叶癌的发病率呈不断上升趋势,尤其是绝经后女性,可能与激素治疗有关

管腔A型：ER 阳性和(或) PR 阳性,Ki-67 增殖指数<14% HER-2阴性
管腔B型：ER阳性和(或)PR阳性,Ki-67 增殖指数≥14%,HER-2 阴性或阳性
HER-2 过表达型：ER、PR 阴性,HER-2 阳性
三阴型：ER、PR、HER-2 均阴性
（-） E-cad
（+）GCDFP-15、 cyclin D1、 cathepsin D、 Bcl-2、 Ck 34BetaE12
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